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Epidemiology, phytotherapy, pneumatic chemistry, Warao indians, culture history, South America. Autor[ Willuhn, G. J[ 16.06 Z. Phytother., 16, No. 6, 325-342, 1995 ; Phytopharmaka in der Dermatologie Phytomedicines in dermatology ; Summary A review on herbal drugs and their preparations used in the treatment of skin ailments is given based on the monographs of the Commission E at the former German Bundesgesundheitsamt. Most of these drugs can be classified as "antiinflammatory" and "wound healing" drugs. The therapeutic effects of phytomedicines used in dermatology mainly are based on these simultaneous effects. For a comparative assessment of phytomedicines prepared from herbal drugs initial product ; the pharmaceutical quality of the various plant extracts made from the drugs active substances ; is of particular significance, because the therapeutical effect can not be attributed to one single substance and the proof of efficacy is still lacking for several of these phytomedicines. The essential active and effecacious principles of some herbal drugs are discussed. Keywords Phytotherapy in dermatology, topical herbal drugs Autor[ Willuhn, G. J[ 16.06 ZPT 24, Nr.6 2003 S. 299-306 Eleutherococcus senticosus: Lieferant der Taigawurzel Eleutherococcus senticosus: The source of the Taiga root ; Zusammenfassung Der in der subarktischen Taiga Ostsibiriens weit verbreitete Strauch Eleutherococcus senticosus Stachelpanax, Araliaceae ; wurde erst zu Beginn der zweiten Hlfte des 20. Jahrhunderts von sowjetischen Wissenschaftlern der medizinischen Nutzung zugefhrt. Die heutige Verwendung seiner Wurzeln und Rhizome Eleutherococcus radix Ph R ; sind das Ergebnis der damals unternommenen Anstrengungen, auf sowjetischem Territorium eine Ersatzdroge fr die Ginseng-Wurzel zu finden. Im Gegensatz zu dieser ist die auch als Taigawurzel oder Sibirischer Ginseng bezeichnete Eleutherococcus-Wurzel praktisch saponinfrei. Bei ihren als Eleutheroside bezeichneten Inhaltsstoffen handelt es sich nicht um eine einheitliche Stoffgruppe, sondern um Lignane, Cumarine, Phenylpropane und Sterole, die auch anderweitig im Pflanzenreich vorkommen. Der Begriff Eleutheroside sollte deshalb eliminiert werden. Die Wirkung der Taigawurzel wird vor allem als adaptiv, stressreduzierend, stimulierend, leistungssteigernd immunmodulierend und antioxidativ beschrieben. Historisch gesehen ist die Taigawurzel eng mit der Entwicklung des Adaptogen-Konzeptes verbunden, das sich noch immer einer naturwissenschaftlichen Besttigung oder Widerlegung entzieht. Trotz der vielen klinischen Untersuchungen ist der Wirksamkeitsnachweis fr die Taigawurzel noch nicht zur Zufriedenheit aller erbracht worden. Das phytochemische Profil und die vielen nachgewiesenen Wirkungen der Taigawurzel und ihrer phenolischen Glykoside machen ihre weitere Erforschung wnschenswert. Summary The Siberian Ginseng Eleutherococcus senticosus ; which is widely spread in the Sub-arctic Taiga region of East Siberia was first introduced into medical utility in the second half of the th 20 Century by Soviet scientists. The current use of its roots and rhizome Eleutherococcus radix Ph. EUR ; are the results of attempts undertaken by Soviet scientists to introduce an alternative to Ginseng radix. In contrast to Ginseng root, the Eleutherococcus radix also referred to as Taiga root or Siberian Ginseng is practically saponin free. Its components designated as.
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In large-scale clinical trials. Selective serotonin reuptake inhibitor SSRI ; utilization: adherence to therapy Ball AT and Hart BA * Welborn Health Plans, 421 East Chestnut Street, Evansville, IN 47713 SUMMARY: The Depression Guideline Panel of the Agency for Health Care Policy and Research AHCPR ; indicates that effectiveness of any treatment is highly influenced by patient adherence, which increases with the education of depressed patients. An initial selective serotonin reuptake inhibitor SSRI ; pharmacy claims analysis was completed in June 1998. Health plan officials thought that patients were started on SSRIs and continued indefinitely without attempting to discontinue medication. Drug and dose stratification, length of therapy, and costs were analyzed. The results of the initial study showed that 41% of new patients started on SSRIs did not continue therapy as recommended by AHCPR guidelines. Based on the results of this study, the health plan took steps to improve SSRI utilization in depression. The plan implemented Rhythms, a patient-education newsletter program targeting patients on antidepressants. Newsletter delivery coincided with the most common times of relapse: remission and discontinuation of therapy. The plan also provided results from this study to the medical staff and educated them about appropriate treatment duration. A follow-up study was completed in February 2000. The results showed a 5% overall improvement in adherence to therapy, with 64% of patients receiving appropriate continuation therapy. The interventions implemented provided a small improvement in adherence to therapy. Currently we are evaluating total medical costs of patients who continued therapy versus those who did not continue therapy for the appropriate period of time to determine if a difference exists in total costs. LEARNING OBJECTIVES: Audience participants will: 1. Review SSRI utilization patterns in a managed health care plan. 2. Understand the depression guideline from the Depression Guideline Panel of the AHCPR. 3. Discuss options for improving adherence to antidepressant therapy in plan members. Use of survey results in managed care decision making Beilfuss, C University of Arizona, P.O. Box 210207, Tucson, AZ 85721-0207 OBJECTIVE: Efficacy, safety, and cost are often the primary factors decision makers examine when making drug benefit decisions. Evidence other than clinical and cost data, such as the effect of multitier copayments on consumer behavior, may also help inform drug benefit decisions. This study examined the use of nonclinical evidence in managed care decision making. METHODS: Attendees at an April 2000 AMCP preconference symposium were asked to complete a 10-item questionnaire regarding their use of nonclinical evidence. RESULTS: Of the 80 participants who completed the questionnaire, 35. Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 101 N 3; March 2007 and atorvastatin.
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A number of studies have demonstrated that resveratrol, a phytoalexin found in grapes and wines, may protect against coronary heart disease as a result of different biological effects and mechanisms, including significant antiaggregatory properties. However, the possible implication of the so-called viniferins resveratrol polymers ; in the cardioprotective effects attributed to the long-term moderate consumption of wine has not been reported yet. Therefore, in this study we have evaluated for the first time the effects of ; -trans-e-viniferin e-viniferin ; , a resveratrol dimer, on platelet function. Washed platelets were obtained by differential centrifugation from buffy coat samples. For aggregation experiments, samples of washed platelets were placed in an optical aggregometer at 37 C under constant stirring and changes in light transmission were registered during 5 min. Changes in cytosolic free calcium [Ca2 + ]i ; were measured in fura-2 loaded platelets by fluorimetry. For measurement of cGMP production, commercially available ELISA kits were used. Finally, serine threonine and or tyrosine phosphorylation was evaluated in platelet lysates by western blot assay and immunodetection with specific antibodies. -Viniferin 1-10 M ; caused a concentration-dependent decrease in platelet aggregation induced by collagen 2.5 g ml ; in washed human platelets with an IC50 value of 2.92 0.16 M. -Viniferin 10 M ; induced a 2-fold increase on basal production of cGMP in human platelets. -Viniferin 1-10 M ; did not modify the basal [Ca2 + ]I in fura-2-loaded platelets but decreased by 25 4% the rise in [Ca2 + ]i elicited by collagen. -Viniferin 1-10 M ; diminished the level of protein phosphorylation at serine threonine and or tyrosine residues increased by collagen. These results suggest that: 1 ; -viniferin may be together with resveratrol ; one of the polyphenols responsible for the cardioprotective effects of wines; 2 ; the antiaggregatory properties of -viniferin seem to be due, at least in part, to its effects on cGMP turnover and platelet protein phosphorylation; 3 ; -viniferin may be of value as a structural template for the design and development of new platelet antiaggregatory drugs.
K82 W. Haverkamp et al. Table 1 Genetic characterization of congenital long QT syndrome and calan!

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