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Asia-Pacific including Japan ; , Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 includes corresponding Graph Chart ; II-90 Table 28: World 10-Year Perspective for Other Drugs by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Europe, Asia-Pacific including Japan ; , Latin America and Rest of World Markets for Years 2000, 2006 & 2010 includes corresponding Graph Chart ; II-91 III.MARKET 1. The United States III-1 A.Market Analysis III-1 Current & Future Analysis III-1 Cost Implications of CNS Disorders III-1 US Prescription Market Slumps Amid Controversies III-2 Alzheimers Market III-2 Table 29: Incidence of Alzheimers Disorder in Major US States: 2000-2025 P ; includes corresponding Graph Chart ; III-2 Anti-Alzheimers Drugs Currently Approved for Use in the US III-3 Table 30: Leading Brands in the US Anti-Alzheimers Market 2004-2005 ; : Percentage Breakdown by Value Sales for Aricept, Namenda, Razadyne Razadyne ER and Exelon includes corresponding Graph Chart ; III-3 Cost of Care to AD Patient III-3 Clinical Pipeline III-3 Anti-Psychotics III-4 Growth Dampeners III-4 Clinical Pipeline III-4 Table 31: Leading Brands in US Anti-Psychotics Market 2004-2006 ; : Percentage Breakdown by Value Sales for Zyprexa, Risperdal, Seroquel, Depakote ER, Abilify, Lamictal XR, Geodon and Others includes corresponding Graph Chart ; III-5 Table 32: Leading Brands in US Atypical Anti-Psychotics Market 2004, 2006 & 2008P ; : Percentage Breakdown by Value Sales for Zyprexa, Risperdal Risperdal CONSTA, Seroquel, Abilify, Geodon and Others includes corresponding Graph Chart ; III-5 Antidepressants III-6 Antidepressants to Feature Black-Box Warnings III-6 Antidepressant Consumption Falls Among Children and Adolescents III-6 Table 33: US Anti-Depressants Market 2004-2006 ; : Sales of Leading Drug Brands - Zoloft, Effexor ER, Lexapro, Wellbutrin, Paxil, Celexa and Prozac includes corresponding Graph Chart ; III-6 Multiple Sclerosis III-7 Table 34: Leading Anti-Multiple Sclerosis Drugs in the US 2004 ; : Percentage Breakdown of Value Sales for Avonex, Copaxone, Rebif and Betaseron includes corresponding Graph Chart ; III-7 Insomnia Market III-7 Rising Consumption of ADHD Drugs Combat Safety Concerns III-7 Table 35: US ADHD Market 2005 ; : Percentage Breakdown of Sales by Leading Brands - Concerta, Strattera, Ritalin, Metadate, Focalin XR and Others includes corresponding Graph Chart ; III-8 Unmet Medical Needs in Neuropathic Pain Offer Growth Prospects III-8 Table 36: Leading Players in the US Pain Management Market.
US Dept. of Health & Human Services.
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Of Janssen-Ortho's patented medicines, Levaquin 5mg mL and 25mg mL, as of March 1, 2005. Pwxil CR, 13 GlaxoSmithKline Inc. In order to comply with the PMPRB's Price Guidelines, GlaxoSmithKline GSK ; undertook to reduce the average transaction price of Pacil CR by the end of the January 1 to June 30, 2005 regulatory filing period such that the average transaction price for 2005 does not exceed the 2005 MNE price of $1.5861 for Paxill CR 12.5 mg and $1.7019 for Pasil CR 25 mg. GSK offset excess revenues it received during the period of January 5, 2004 to December 31, 2004 by making a payment to the Government of Canada in the amount of $310, 403.64. Tamiflu, 14 Hoffmann-La Roche Limited In order to comply with the PMPRB's Price Guidelines, Hoffmann-La Roche Limited Roche ; agreed that the MNE price of Tamiflu 75 mg capsule was $3.7695 for the period January to December 2003; $3.8383 for the period January to December 2004; and is $3.8917 for the period January to December 2005. Also, Roche offset excess revenues received for the reporting periods January 1, 2003 to December 31, 2004 by making a payment to the Government of Canada in the amount of $442, 973.47. Quasi-judicial Activities Nicoderm, Hoechst Marion Roussel Canada Inc. On April 20, 1999, the Board issued a Notice of Hearing to consider whether, under sections 83 and 85 of the Patent Act, Nicoderm is being, or has been, sold by Hoechst Marion Roussel Canada Inc. HMRC ; in Canada at a price that, in the opinion of the Board, is excessive and if so, what order, if any, should be made. The matter was reported on in previous Performance Reports, Annual Reports and selected issues of the NEWSletter. Following the issuance of the Board's decisions in 1999 and 2000 affirming its jurisdiction to conduct a hearing into the price of Nicoderm, HMRC commenced two judicial review applications in the Federal Court of Canada seeking to set aside the Board's decisions. The Federal Court heard the judicial review applications in this matter on May 16-17, 2005. Decisions are pending and plavix.
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Purpose: To determine the maximum-tolerated dose, toxicity profile, and pharmacokinetics of a fixed dose of paclitaxel followed by increasing doses of carboplatin, given weekly to patients with advanced esophageal or gastric junction cancer. Experimental Design: Paclitaxel was administered on day 1 as a 1-h infusion at a fixed dose of 100 mg m2 followed by a 1-h infusion of carboplatin targeting an area under the curve AUC ; of 25 mg min ml, with cycles repeated on days 8, 15, 29, and 43. Results: Forty patients [36 males; median range ; age, 57 40 74 ; years] were enrolled. Dose-limiting toxicity was observed at a carboplatin AUC of 5 mg min ml and consisted of treatment delay attributable to myelosuppression. No grade 3 4 treatment-related nonhematological toxicity was observed. The highest dose intensity 95% of the planned dose over time ; was achieved with a carboplatin AUC of 4 mg min ml. The mean SD ; AUCs of unbound Cu ; and total paclitaxel were 0.662 0.186 and 7.37 1.33 M h, respectively. Clearance of Cu was 188 44.6 liter h m2, which is not significantly different from historical data P 0.52 ; . Cremophor EL clearance was 123 23 ml h m2, similar to previous findings. Of 37 patients evaluable for response, 1 had complete response, 19 had partial response, and 10 had stable disease, accounting for an overall response rate of 54%. Conclusions: This regimen is very tolerable and effective, and the recommended doses for additional studies are paclitaxel 100 mg m2 ; , with carboplatin targeting an AUC of 4 mg min ml.
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